In order to increase medication absorption, current research was concentrated on the formulation and assessment of a fast-dissolving tablet of hydroxyzine hydrochloride based on natural gum using a 32-factorial design. The direct compression technique was applied. Asam jawa mucilage (x1) and Ac-Di-Sol (x2) were considered as independent variables with three levels (+1, 0, -1). Based on preliminary studies, the level two components were chosen and their impact on the dependent variable (disintegration time) was calculated. The parameters ranging from hardness 2.1-2.6 kg/cm2, thickness 2.227-2.296 mm, weight variance 182-196 mg, wetting time 58-68 seconds, water absorption ratio 0.1628-0.2439, disintegration time 56 sec – 9 min, friability 0.53-0.68 % and cumulative drug release 88.79 – 99.87 % were assessed for the formulated tablets. To get the experimental design, model the response surface and compute the static assessment, the program design expert (11.0) was utilized. The formulation tests (F1 through F10) for tablet parameters were found to be within the prescribed range. 56 seconds was the disintegration time and the cumulative drug release ranged from 86.79% to 98.50%. Batch F6 was noted as a batch with promise.
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